Frequency and Localization of Second Primary Tumors in Patients with Oropharyngeal Carcinoma—The Influence of the Human Papilloma Virus

Purpose: To investigate the frequency, localization, and survival of second primary tumors (SPT) oropharyngeal squamous cell carcinoma (OPSCC) depending on human papillomavirus (HPV) status. Methods: We performed a retrospective chart analysis 107 OPSCC patients treated at Zurich University Hospital from 2001 to 2010. Rate localization SPT after an index were stratified according smoking HPV infection Results: In total, 57/91 (63%) included showed HPV-associated OPSCC. Of these, 37/57 (64.9%) with HPV-positive 32/34 (94.1%) HPV-negative smokers. The median age diagnosis was 59.54 years (interquartile range 52.7–65.6). addition, 8/57 (14%) 13/34 (38.2%) developed SPT. rate in significantly lower than (p-value 0.01). Smokers more head neck area outside. development led time patients, while it did not affect patients. Conclusions: Patients had risk developing tumors. If developed, shorter